After disseminating a significant update, shares of MAIA Biotechnology, Inc. (NYSE: MAIA) sustained the momentum from the prior session, continuing to rally into the extended trading session on Thursday. As of the latest review, MAIA stock saw a 6.63% increase on the US charts, reaching $3.54, following a 2.79% rise during regular trading, closing at $3.32.
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Key Achievements And Clinical Progress
MAIA Biotechnology (MAIA) has disclosed noteworthy company highlights and key achievements for the year thus far, emphasizing recent clinical progress for its leading candidate, THIO. THIO, a potential first-in-class cancer telomere targeting agent, is currently under clinical development to assess its efficacy in treating non-small cell lung cancer (NSCLC).
The company’s pioneering approach to cancer therapy is bolstering a strong value proposition for its portfolio of innovative anticancer compounds. Recent clinical data indicate THIO’s promising disease control, response rates, and patient benefits post-therapy. Notably, third-line treatment with THIO has significantly outperformed existing standard-of-care data in NSCLC.
During the recent ASCO 2024, MAIA’s poster presentation and future study plans across various geographies garnered significant positive feedback and enthusiasm from oncologists and investigators, both domestically and internationally, further validating the growing impact of their cancer treatment initiatives.
Clinical Trial Developments And Strategic Goals
THIO operates via a dual mechanism designed to induce telomeric DNA damage and enhance cancer-specific immune responses. The Phase 2 THIO-101 clinical trial is currently evaluating THIO in combination with an immune checkpoint inhibitor (CPI), cemiplimab, for patients with advanced NSCLC who have failed two or more prior standard-of-care therapies. MAIA successfully secured a valuable clinical supply agreement for cemiplimab, essential for the THIO-101 trial.
THIO has demonstrated efficacy across all doses with an excellent safety profile, but the 180mg dose has shown the highest efficacy and is well tolerated compared to existing therapies. Consequently, MAIA has selected 180mg per cycle as the preferred dose for future use. For this heavily pre-treated patient population, comparative third-line data is scarce, making MAIA’s trial the first to provide substantial data for CPI-resistant patients.
Looking ahead, MAIA’s Phase 2 THIO-101 clinical trial is anticipated to reach completion in 2024. The company is also actively engaged in research and development for a portfolio of second-generation THIO-like compounds, continuing its pursuit of innovative cancer therapies.
